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Figure 12 | BMC Biochemistry

Figure 12

From: Comparison of Mycobacterium tuberculosis isocitrate dehydrogenases (ICD-1 and ICD-2) reveals differences in coenzyme affinity, oligomeric state, pH tolerance and phylogenetic affiliation

Figure 12

M. tb ICD-2 is closer to prokaryotic NADP+ ICDs. Rooted neighbour joining phylogenetic tree of M. tb ICD-2 with Thermotoga maritima as outgroup. The numerical values represent the confidence assessed by bootstrap analysis. ICD-2 clusters with NADP+ dependent ICDs of gram-ve bacteria. M. tb ICD-2 has closest homology with Mycobacterium leprae showing 85.4% similarity at protein level. Other close neighbours are human pathogens like Pseudomonas aeruginosa (65%), Vibrio cholerae (60%), Neisseria menengitidis (59%) etc.

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