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Figure 11 | BMC Biochemistry

Figure 11

From: Comparison of Mycobacterium tuberculosis isocitrate dehydrogenases (ICD-1 and ICD-2) reveals differences in coenzyme affinity, oligomeric state, pH tolerance and phylogenetic affiliation

Figure 11

M. tb ICD 1 is closer to eukaryotic NADP+ ICDs. A 50% consensus bootstrap neighbour joining tree of M. tb ICD-1 with Thermotoga maritima as outgroup. The numerical values represent the confidence assessed by bootstrap analysis. The tree depicts a closer lineage of M. tb ICD-1 with eukaryotic NADP dependent isocitrate dehydrogenases. The amino acid sequence alingnment of ICDs from these organisms showed more than 65% identity with all the major catalytically important residues conserved (refer text).

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BMC Biochemistry

ISSN: 1471-2091

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