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Figure 1 | BMC Biochemistry

Figure 1

From: Analysis of Escherichia coli nicotinate mononucleotide adenylyltransferase mutants in vivo and in vitro

Figure 1

Biosynthesis of NAD in bacteria. Abbreviations: Na, nicotinic acid; Nm, nicotinamide; NMN, nicotinamide mononucleotide; NAMN, nicotinic acid mononucleotide; NmR, nicotinamide ribonucleoside; NAAD, nicotinic acid adenine dinucleotide; NAD, nicotinamide adenine dinucleotide; NADP, nicotinamide adenine dinucleotide phosphate. Enzymes: nadA codes for quinolinate synthase; nadB L-aspartate oxidase; nadC quinolinic acid phosphoribosyltransferase; nadD nicotinic acid mononucleotide adenylyltransferase; nadE NAD synthetase; nadK (nadF) NAD kinase; pncA nicotinamide deamidase; pncB nicotinic acid phosphoribosyltransferase; pncC NMN deamidase; nadV* Nm phosphoribosyltransferase (in Haemophilus ducreyi); ligase+? DNA ligase, only partially responsible for the activity; nadR bifunctional activity; a)* N-ribosylnicotinamide kinase, b)* NMN adenylyltransferase (in H. influenzae); 1) NMN glycohydrolase (gene not yet identified). Some of these steps may occur in the periplasmic space or at the inner membrane. Asterisks indicate activities not identified in vivo in E. coli.

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