Table 2 Inhibition of Na+/K+-ATPase from pig kidney by antibiotics
From: Archazolid and apicularen: Novel specific V-ATPase inhibitors
specific activity μmol*mg-1 *min-1 | ||
|---|---|---|
experiment 1 | experiment 2 | |
control without inhibitors | 19.0 | 15.9 |
vanadate 0.1 mM | 2.0 | n. d. |
vanadate 1 mM | 0 | 0 |
ouabain 0.1 mM | 5.2 | n. d. |
ouabain 1 mM | 0 | 0 |
concanamycin A 1 μM | 16.7 | 12.7 |
apicularen A 1 μM | 17.3 | 13.2 |
archazolid A 1 μM | 17.1 | 12.2 |