Archazolid and apicularen: Novel specific V-ATPase inhibitors

BMC Biochemistry

Table 1 Growth inhibition of different mammalian cell lines by antibiotics

Cell line	Origin	ArcA	ArcB	ApiA	ApiB	BafA₁	ConA
		IC₅₀ (nM)
L-929	murine connective tissue	0.81^a	1.1^a	4.5	620	3.2^a	0.23^a
3Y1	rat, embryogenic fibroblast cell line	0.95	1.1	3.2	310	5.6	1.4
KB-V1^b	human cervix carcinoma	48.0	35.0	23.0	1600	7.2	28.0
KB-V1^b	(in presence of 11 μM verapamil)	2.3	1.5	7.9	540	4.0	2.7
A-594	human lung carcinoma	0.54	0.69	0.23^c	310^c	0.4	0.17
M1	mouse, embryogenic fibroblast cell line	0.27	0.35	1.4	190	2.6	0.56

ISSN: 1471-2091