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Table 3 Second-order rate constants of wtPAI-1, D355P, R356P, P357G toward tPA or uPA.

From: Distal hinge of plasminogen activator inhibitor-1 involves its latency transition and specificities toward serine proteases

 

tPA(M-1s-1)

uPA(M-1s-1)

wtPAI-1

1.7 ± 0.6 × 107

4.4 ± 1.6 × 107

D355P

2.0 ± 0.7 × 107

5.1 ± 1.7 × 107

R356P

1.3 ± 0.5 × 107

4.7 ± 1.7 × 107

P357G

1.6 ± 0.7 × 107

4.9 ± 2.5 × 107

  1. The second-order rate constants of inhibition, expressed in M-1 s-1 were determined as described in the Materials and Methods section. Values are averages of at least four independent experiments.
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