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Table 2 Comparison of variable region of protease domain in serine proteases

From: Distal hinge of plasminogen activator inhibitor-1 involves its latency transition and specificities toward serine proteases

Protease

Constant region 1

Variable region

Constant region 2

tPA

PWQAAI

FAKHRR SPGER F

LCGG

uPA

PWFAAI

YRRHR GGSVTY

VCGG

Plasmin

PWQVSL

R TR FGMH

FCGG

Thrombin

PWQVM

FRK SPQEL

LCGA

  1. Alignments of the amino acids sequences of the first variable region and parts of the surrounding constant regions of the protease domain of tPA, uPA, plasmin and thrombin. In the variable region positively charged amino acid residues are underlined.
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BMC Biochemistry

ISSN: 1471-2091

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