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Table 1 Comparative inhibition of kynureninase from different sources by synthetic substrate analogues.

From: Comparative inhibition by substrate analogues 3-methoxy- and 3-hydroxydesaminokynurenine and an improved 3 step purification of recombinant human kynureninase.

Source

KI (4) / (nM)

KI (8) / (μM)

Bacterial

100

10

Rat

40

175

Human

5

15

  1. The inhibition constants (KI) were determined from the figures 4 and 5 for 3-hydroxydesaminokynurenine (4) and those for 3-methoxydesaminokynurenine (5) were determined in a similar fashion (graphs not shown).