Figure 6From: Comparative inhibition by substrate analogues 3-methoxy- and 3-hydroxydesaminokynurenine and an improved 3 step purification of recombinant human kynureninase.Synthesis of inhibitors a) (CH3)3COCl, pyridine, 0°C (79%); b) CuBr, ethyl acetate, CHCl3, reflux, 4 hr (63%); c) NaH, AcNHCH(CO2Et)2, DMF, 0°C (57%); d) HCl, diethyl ether, reflux, 6 hr (76%)Back to article page