| |
Control
|
Hypothyroid
|
|---|
|
Heart weight (g)
|
1.23 ± 0.03
|
0.64 ± 0.04*
|
|
Body weight (g)
| | |
|
Before PTU treatment
|
206 ± 4
|
205 ± 4
|
|
After PTU treatment
|
441 ± 19
|
275 ± 20*
|
|
Heart weight:body weight (×100)
|
0.28 ± 0.02
|
0.23 ± 0.03*
|
| |
nmol/mg heart
|
|
CL content
|
6.1 ± 0.1
|
4.3 ± 0.4*
|
| |
pmol/min·mg protein
|
|
CL synthase activity
|
3.1 ± 0.3
|
2.1 ± 0.2*
|
|
MLCL AT activity
|
40 ± 6
|
26 ± 3*
|
- Rats were made hypothyroid by administration of 0.05% PTU in the drinking water for 34 days. The hearts were harvested, weighed and CL content, CL synthase and MLCL AT activities determined. Results represent the mean ± standard deviation of ten animals *p < 0.025.
