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Table 1 Body weight, heart weight, heart CL content, CL synthase and MLCL AT activities in normal and hypothyroid rats.

From: Expression of monolysocardiolipin acyltransferase activity is regulated in concert with the level of cardiolipin and cardiolipin biosynthesis in the mammalian heart

 

Control

Hypothyroid

Heart weight (g)

1.23 ± 0.03

0.64 ± 0.04*

Body weight (g)

  

   Before PTU treatment

206 ± 4

205 ± 4

   After PTU treatment

441 ± 19

275 ± 20*

Heart weight:body weight (×100)

0.28 ± 0.02

0.23 ± 0.03*

 

nmol/mg heart

CL content

6.1 ± 0.1

4.3 ± 0.4*

 

pmol/min·mg protein

CL synthase activity

3.1 ± 0.3

2.1 ± 0.2*

MLCL AT activity

40 ± 6

26 ± 3*

  1. Rats were made hypothyroid by administration of 0.05% PTU in the drinking water for 34 days. The hearts were harvested, weighed and CL content, CL synthase and MLCL AT activities determined. Results represent the mean ± standard deviation of ten animals *p < 0.025.
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BMC Biochemistry

ISSN: 1471-2091

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