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Table 1 Body weight, heart weight, heart CL content, CL synthase and MLCL AT activities in normal and hypothyroid rats.

From: Expression of monolysocardiolipin acyltransferase activity is regulated in concert with the level of cardiolipin and cardiolipin biosynthesis in the mammalian heart

  Control Hypothyroid
Heart weight (g) 1.23 ± 0.03 0.64 ± 0.04*
Body weight (g)   
   Before PTU treatment 206 ± 4 205 ± 4
   After PTU treatment 441 ± 19 275 ± 20*
Heart weight:body weight (×100) 0.28 ± 0.02 0.23 ± 0.03*
  nmol/mg heart
CL content 6.1 ± 0.1 4.3 ± 0.4*
  pmol/min·mg protein
CL synthase activity 3.1 ± 0.3 2.1 ± 0.2*
MLCL AT activity 40 ± 6 26 ± 3*
  1. Rats were made hypothyroid by administration of 0.05% PTU in the drinking water for 34 days. The hearts were harvested, weighed and CL content, CL synthase and MLCL AT activities determined. Results represent the mean ± standard deviation of ten animals *p < 0.025.