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Table 1 Mutations introduced into the predicted PEST sequence of CFTR

From: The PEST sequence does not contribute to the stability of the cystic fibrosis transmembrane conductance regulator

Mutant Sequence PEST Score
Wild-type (WT) 716 – KTPLQMNGIEEDSDEPLER – 734 +6.91
Poly-Valine 716 – KTPLQMNGIVVVVVV PLER – 734 -26.19
E725K/E726K 716 – KTPLQMNGIKK DSDEPLER – 734 N/A
S728A 716 – KTPLQMNGIEEDA DEPLER – 734 +4.07
T717A/E725K 716 – KA PLQMNGIK EDSDEPLER – 734 N/A
  1. * Residues in bold are the mutations introduced.