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Table 1 Mutations introduced into the predicted PEST sequence of CFTR

From: The PEST sequence does not contribute to the stability of the cystic fibrosis transmembrane conductance regulator

Mutant

Sequence

PEST Score

Wild-type (WT)

716 – KTPLQMNGIEEDSDEPLER – 734

+6.91

Poly-Valine

716 – KTPLQMNGIVVVVVV PLER – 734

-26.19

E725K/E726K

716 – KTPLQMNGIKK DSDEPLER – 734

N/A

S728A

716 – KTPLQMNGIEEDA DEPLER – 734

+4.07

T717A/E725K

716 – KA PLQMNGIK EDSDEPLER – 734

N/A

  1. * Residues in bold are the mutations introduced.
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BMC Biochemistry

ISSN: 1471-2091

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