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Figure 3 | BMC Biochemistry

Figure 3

From: The PEST sequence does not contribute to the stability of the cystic fibrosis transmembrane conductance regulator

Figure 3

Biosynthetic Maturation of CFTR PEST Mutants. A) Pulse-chase radiograph for non-processing defective constructs: WT, WT/E725K/E726K, and WT/T717A/E725K; results for WT/S728A not shown, but is similar to that of WT. B) Pulse-chase radiograph for processing defective constructs: ΔF508, ΔF508/poly-valine, ΔF508/E725K/E726K, and ΔF508/T717/E725K; results for WT/Poly-valine and ΔF508/S728A not shown but they show similar results as ΔF508. Pulse-chase experiments and immunoprecipitation were performed as described in the "Materials and Methods" section.

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BMC Biochemistry

ISSN: 1471-2091

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