Table 2 Sequence alignment of the mouse 5-HT₃R with the mouse nicotinic α7 receptor and the AChBP. Two sequences are shown. The top sequence is the putative D loop containing W89 and R91 (homologous to W53 and Q55 of the AChBP). The lower sequence shows the putative E loop and contains Y140, Y142 and Y152 (homologous to L102, R104 and M114 of the AChBP).

53

55

E

V

N

E

I

T

N

E

V

D

V

V

F

W

Q

Q

T

T

W

S

N

V

D

E

K

N

Q

V

L

T

T

Y

I

W

Y

R

Q

Y

W

T

D

V

D

E

K

N

Q

V

L

T

T

N

I

W

L

Q

M

S

W

T

102

104

114

V

L

T

P

Q

L

A

R

V

V

S

D

G

E

V

L

Y

M

P

S

P

N

I

P

-

Y

V

Y

V

H

H

R

G

E

V

Q

N

Y

K

P

A

T

F

H

T

N

V

L

V

N

S

S

G

H

C

Q

Y

L

P

P