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Figure 4 | BMC Biochemistry

Figure 4

From: Identification of critical residues in loop E in the 5-HT3ASR binding site

Figure 4

Inhibition of [3H]granisetron binding by 5-HT 3 R ligands. The data represent the combined results of at least four experiments. Assays were conducted as described in Materials and Methods. Fractional response is the fraction of [3H]granisetron binding obtained in the presence and absence of inhibitor. An IC50 value was determined from the data using non-linear curve fitting as described in the methods and the Ki value calculated using the Cheng-Prusoff equation, the Kd as determined in Figure 3 and the concentration of ligand used to obtain the inhibition data. Kd values are reported in Table 3. A. 5-HT B. m CPBG C. d tC D. Lerisetron

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