Figure 7
From: Differential modulation of cellular death and survival pathways by conjugated bile acids
Expression of asbt in McArdle RH-7777 cells and induction of caspase 8 activity. (A) Uptake of TCA was enhanced in McArdle RH-7777 cells expressing asbt. (B) Treatment of asbt- expressing McArdle RH-7777 with GCDCA (right bar), but not with TCA (middle bar), showed activation of caspase 8 activity. The values shown are mean ± SD (n = 6). Differences in comparison to controls were evaluated using a Student's t test. *P < 0.05. The experiment in (A) was repeated twice and the experiment in (B) was repeated three times with similar results.