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Figure 2 | BMC Biochemistry

Figure 2

From: Plasmodium falciparum UvrD activities are downregulated by DNA-interacting compounds and its dsRNA inhibits malaria parasite growth

Figure 2

Analysis of ATPase inhibition kinetics. Concentration curves of compounds A. Netropsin, B. Daunorubicin, C. Nogalamycin, D. ethidium bromide and E. Ciprofloxacin. In each panel, the autoradiogram of the assay is shown on the left and the quantitative data on the right side. Lane C in all the panels is control without enzyme and lane 1 in all the panels is reaction with enzyme without the addition of any compound. Lanes 2–8 are reactions with enzyme in the presence of 0.2, 0.5, 1, 2, 3, 4 and 5 μM compounds labeled below the autoradiogram. Inhibition kinetics of ciprofloxacin was performed using 0.5-30 μM concentration. The position of ATP and released Pi is shown on the left side of the autoradiogram.

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BMC Biochemistry

ISSN: 1471-2091

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