Figure 2
From: Chemical-genetic induction of Malonyl-CoA decarboxylase in skeletal muscle
The development of diet-induced obesity and insulin resistance in Tg-fMCDskelmice. (A) Experimental timeline of control and Tg-fMCDskel mice placed on low fat diet (LFD) or high fat diet (HFD) followed by treatment of Shield-1 to induce MCD within the skeletal muscle. (B) Mice were weighed weekly to monitor body weight gain. (C) Confirmation of glucose intolerance by glucose tolerance test (GTT). (D) Area under the curve for GTT and (E) insulin at 15 min after glucose challenge in control and Tg-fMCDskel mice. (F) Insulin tolerance test (ITT) confirms insulin resistance in mice fed the high fat diet. (n = 5-8) Data are expressed as means +/- SEM.