Figure 1
From: Chemical-genetic induction of Malonyl-CoA decarboxylase in skeletal muscle
Tissue specific chemically inducible Malonyl-CoA Decarboxylase. (A) Schematic diagram of the dually regulated MCD transgene. (B) Tg-fMCDskel mice were injected i.p. with vehicle or Shield-1 at various doses. Samples were collected 24Â hours after injection and gastrocnemius muscle samples were probed for the indicated proteins. (C) Dose and delivery vehicle analysis of Shield-1 in Tg-fMCDskel mice. Gastrocnemius muscles from mice injected i.p. with vehicle or Shield-1 at varying doses and delivery methods were collected 24Â hours post treatment to determine efficacy of Shield-1 stabilization by western blot for FKBP12.