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Table 1 Dissociation constants for inhibition of thrombin binding to HCII 1-75 (SPR)

From: The complete N-terminal extension of heparin cofactor II is required for maximal effectiveness as a thrombin exosite 1 ligand

Inhibitor

Ki(μM)

HCII 1-75

2.6 ± 0.6

HCII 54-75

8.5 ± 2

HCII 1-53

No inhibition

HCII 54-75 and HCII 1-53

13 ± 3

Hir 55-65

0.29 ± 0.07

sulfo-Hir 54-65

0.054 ± 0.09

  1. The mean of 3 determinations ± the standard deviation (SD) is shown.
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BMC Biochemistry

ISSN: 1471-2091

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