| Serpin with M358R loop | Serpin with RCL5 loop | |||
---|---|---|---|---|---|
Protease | API M358R | HV3API | HAPI M358R | API RCL5 | HV3 API RCL5 |
M358R | |||||
α-thrombin (×106 M-1 min-1) | 22 ± 4 | 72 ± 15*** | 186 ± 32*** | 35 ± 8 | 66 ± 8*** |
γT-thrombin (×106 M-1 min-1) | 5.9 ± 0.1 | 11 ± 3** | 34 ± 10** | 15 ± 0.8 | 21 ± 3*** |
APC (×106 M-1 min-1) | 1.7 ± 0.1 | 1.9 ± 0.2 | 1.7 ± 0.2 | 0.0038 ± 0.0013a | 0.022 ± 0.005*** |
α-thrombin/ APC ratio | 13 | 39 | 109 | 9,211 | 3000 |