Figure 4

Structure transitions of the CUGBP2 and R3δ isoforms. (A) Initial structure of the CUGBP2 RRM3. The structure was predicted using CUGBP1 RRM3 (2rq4a) because the amino acid sequences of RRM3 of CUGBP1 and 2 are almost identical. (B) MD simulation of the CUGBP2 RRM3. MD simulation was performed for 5 ns. (C) Initial structure of the R3δ isoform RRM3. The RRM3 and the linker residues of the R3δ isoform were analyzed by comparative modeling by SFAS in PBDj. (D) MD simulation of the R3δ isoform. The result of comparative modeling was used for MD simulation for 5 ns to analyze the folding and stability of the predicted structure.