Figure 10
From: Presenilin-1 regulates the constitutive turnover of the fibronectin matrix in endothelial cells
Increased binding of biotinylated fibronectin to PS1−/− endothelial cells. p43 wild type (A, C, E) and p41 PS1−/− (B, D, F) endothelial cells were loaded overnight with 20 μg/ml of biotinylated fibronectin. Cells were fixed and stained with Alexa488-conjugated streptavidin and then imaged by confocal microscopy. Panels A and B show cultures labeled for biotinylated fibronectin. Panels C and D show the same fields stained for DAPI and merged images are shown in panels E and F. Scale bar 10 μm.