Figure 1From: Presenilin-1 regulates the constitutive turnover of the fibronectin matrix in endothelial cellsIncreased immunohistochemical staining of blood vessels in PS1−/− embryonic brain with fibronectin. Shown are neocortical sections from E15.5 wild type (A, C, E) and PS1−/− (B, D, F) embryonic brain double stained with anti-fibronectin (FN) antibodies (C, D) and the Bandeiraea (Griffonia) simplicifolia (BSI-B4) lectin (E, F). Panels A and B show DAPI staining of the same sections. Matched sections were photographed under the same conditions. Note the increased vascular staining in the PS1−/− embryo with fibronectin compared to the lectin staining which is equally intense in the wild type and PS1−/− embryo. Scale bar 50 μm.Back to article page