Table 4 Biochemicals in nucleotide, cofactors and vitamins, and xenobiotic Pathways
From: Metabolomic profiling reveals a role for CPT1c in neuronal oxidative metabolism
PATHWAY | SUB PATHWAY | BIOCHEMICAL NAME | KEGG | CPT1c KO CPT1c WT | Welch's Two-Samplet-Test | CAS | PUBCHEM |
|---|---|---|---|---|---|---|---|
Nucleotide | Purine metabolism, (hypo)xanthine/inosine containing | xanthine | C00385 | 1.02 | 0.7727 | 69-89-6; | 1188 |
hypoxanthine | C00262 | 0.98 | 0.4343 | 68-94-0; | 790 | ||
inosine | Â | 1.00 | 0.8754 | 58-63-9; | Â | ||
Purine metabolism, adenine containing | adenine | C00147 | 1.11 | 0.0801 | 73-24-5; | 190 | |
adenosine | C00212 | 0.86 | 0.1407 | 58-61-7; | 60961 | ||
N1-methyladenosine | C02494 | 0.94 | 0.3601 | 15763-06-1; | 5460178 | ||
adenosine 2'-monophosphate (2'-AMP) | C00946 | 1.00 | Â | 130-49-4; | Â | ||
adenosine 5'-monophosphate (AMP) | C00020 | 0.89 | 0.2000 | 149022-20-8; | 15938965 | ||
Purine metabolism, guanine containing | guanosine | C00387 | 1.01 | 0.9130 | 118-00-3; | 6802 | |
Purine metabolism, urate metabolism | urate | C00366 | 1.06 | 0.4983 | 69-93-2;120K5305; | Â | |
allantoin | C02350 | 0.76 | 0.1685 | 97-59-6; | 204 | ||
Pyrimidine metabolism, cytidine containing | cytidine | C00475 | 0.94 | 0.1562 | 65-46-3; | 6175 | |
cytidine 5'-monophosphate (5'-CMP) | C00055 | 1.01 | 0.8988 | 63-37-6; | 7058165 | ||
Pyrimidine metabolism, orotate containing | orotate | C00295 | 0.86 | 0.2325 | 50887-69-9; | 967 | |
Pyrimidine metabolism, uracil containing | uracil | C00106 | 0.97 | 0.5212 | 66-22-8; | 1174 | |
uridine | C00299 | 0.91 | 0.0141 | 58-96-8; | 6029 | ||
pseudouridine | C02067 | 0.99 | 0.7648 | 1445-07-4; | Â | ||
Purine and pyrimidine metabolism | methylphosphate | Â | 0.85 | 0.1460 | 7023-27-0; | 13130 | |
Cofactors and vitamins | Ascorbate and aldarate metabolism | ascorbate (Vitamin C) | C00072 | 0.87 | 0.1924 | 134-03-2; | Â |
dehydroascorbate | C05422 | 1.70 | 0.2338 | 490-83-5; | 835 | ||
threonate | C01620 | 0.96 | 0.5529 | 70753-61-6; | 151152 | ||
Hemoglobin and porphyrin | heme* | C00032 | 0.69 | 0.3695 | 14875-96-8; | Â | |
Nicotinate and nicotinamide metabolism | nicotinamide | C00153 | 1.00 | 0.9275 | 98-92-0; | 936 | |
nicotinamide adenine dinucleotide (NAD+) | C00003 | 0.87 | 0.0469 | 53-84-9; | 1,089,765,158,925,280,000 | ||
Pantothenate and CoA metabolism | pantothenate | C00864 | 0.94 | 0.7951 | 137-08-6; | 6613 | |
phosphopantetheine | C01134 | 0.85 | 0.0841 | NA; | 115254 | ||
Pyridoxal metabolism | pyridoxal | C00250 | 1.05 | 0.5803 | 65-22-5; | 1050 | |
Riboflavin metabolism | flavin adenine dinucleotide (FAD) | C00016 | 0.93 | 0.1085 | 146-14-5;84366-81-4; | 643975 | |
riboflavin (Vitamin B2) | C00255 | 0.93 | 0.2187 | 83-88-5; | 493570 | ||
flavin mononucleotide (FMN) | C00061 | 0.96 | 0.7167 | 130-40-5; | 710 | ||
Tocopherol metabolism | alpha-tocopherol | C02477 | 1.04 | 0.6234 | 59-02-9;10191-41-0; | 14985 | |
Xenobiotics | Chemical | glycolate (hydroxyacetate) | C00160 | 1.06 | 0.7194 | 79-14-1; | 3,698,251,757 |
glycerol 2-phosphate | C02979,D01488 | 1.02 | 0.9683 | 819-83-0; | 2526 | ||
2-phenoxyethanol | Â | 0.94 | 0.9231 | 122-99-6; | Â | ||
2-pyrrolidinone | Â | 0.84 | 0.6590 | 616-45-5; | 12025 | ||
Food component/Plant | ergothioneine | C05570 | 0.88 | 0.0968 | 58511-63-0; | 3032311 | |
Sugar, sugar substitute, starch | erythritol | C00503 | 0.89 | 0.0966 | 149-32-6; | Â |