Figure 4From: Structural analysis of Brucella abortus RicA substitutions that do not impair interaction with human Rab2 GTPaseGeneral model illustrating the overlap between regions necessary for folding and regions required for protein-protein interaction. If the overlap between folding and interaction regions is high, the probability to isolate substitutions impairing protein-protein interaction without preventing folding may be high (A), low (B) or very low (C).Back to article page