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Table 3 Peak area ratios of the peptide cleavage product divided by the internal standard peptide obtained from the Endopep-MS reaction of BoNT/B with its peptide substrate in the presence of the antibody panel.

From: Extraction and inhibition of enzymatic activity of botulinum neurotoxins /B1, /B2, /B3, /B4, and /B5 by a panel of monoclonal anti-BoNT/B antibodies

Antibody

BoNT/B1

BoNT/B2

BoNT/B3

BoNT/B4

BoNT/B5

None

0.43

1.65

0.72

0.48

0.73

CR2

0.38

1.59

0.79

0.51

1.08

6A12

0.78

2.16

0.93

0.35

0.87

A12

0.76

2.11

0.83

0.53

0.96

B12.2

0.68

2.24

0.85

0.53

0.89

B8.1

0.66

2.13

0.95

0.48

1.06

B12.1

0.63

1.75

1.03

0.48

1.30

2B18.2

0.62

1.83

0.8

0.56

1.24

2B24

0.57

1.78

0.74

0.53

1.07

B1.1

0.56

2.31

0.81

0.54

1.72

2B18.1

0.55

1.39

0.88

0.61

1.09

1B18.1

0.51

2.22

1.07

0.68

0.45

2B30

0.50

1.84

1.29

0.93

0.58

2B23

0.46

1.45

0.85

0.56

1.32

B11E8

0.44

2.44

0.89

0.51

0.82

2B18.3

0.44

2.16

0.75

0.64

0.76

1B12.4

0.40

1.28

0.89

0.77

1.18

4B19.1

0.38

1.49

0.92

0.71

0.60

1B22.4

0.37

1.58

0.92

0.28

0.80

1B12.3

0.35

1.31

0.68

0.70

1.07

B6.1

0.32

2.08

0.87

0.32

1.49

1B22

0.31

1.64

1.04

0.27

0.71

2B29

0.30

1.75

0.98

0.42

0.65

2B27

0.28

1.01

0.62

0.24

0.72

2B25.1

0.27

1.01

0.87

0.25

0.70

1B10.1

0

0.02

0.19

0.10

0.65

  1. Five different subtypes of BoNT/B were used, and they include /B1, /B2, /B3, /B4, and /B5.