Figure 8

PXR-ligand interactions. Interaction map between the secondary bile acid lithocholic acid and PXRs. Key residues involved in binding are listed for human, Tetraodon (tn), and zebrafish (z) PXRs (the residue number is for human). Conserved resides throughout the three species are highlighted by black boxes. The hydrogen bond is shown by a green dashed line, the electrostatic charge interaction is presented as a blue dashed line, and the hydrophobic interaction is depicted as an orange dashed line. The ligand is shown as ball and stick presentation and colored according to atom types (gray = carbon, red-oxygen).