Skip to main content
Figure 7 | BMC Biochemistry

Figure 7

From: The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species

Figure 7

Pharmacophore models of Tetraodon VDR, PXR, and FXR. Pharmacophore models were developed for A) Tetraodon VDR (tnVDR), B) Tetraodon PXR (tnPXR), and C) Tetraodon FXR (tnFXR) using the HipHop method in Catalyst™. The structure-activity data used to develop the pharmacophore models are summarized in Additional File 6. A) The tnVDR pharmacophore contains 4 hydrophobes (cyan) and two hydrogen bond acceptors (green). 1,25-Dihydroxyvitamin D3 (calcitriol) was mapped to the pharmacophore. B) The tnPXR pharmacophore contains three hydrophobes (cyan) and one hydrogen bond acceptor (green). Taurochenodeoxycholic acid was mapped to the pharmacophore. C) The tnFXR pharmacophore contains four hydrophobes (cyan), one hydrogen bond acceptor (green), and one negative ionizable feature (blue). GW4064 was mapped to the pharmacophore.

Back to article page

BMC Biochemistry

ISSN: 1471-2091

Contact us