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Figure 3 | BMC Biochemistry

Figure 3

From: The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species

Figure 3

PXR concentration-response curves. Ligand activation of PXRs from different species. A) T-0901317 activates human PXR (hPXR) and chicken PXR (chPXR) but not Tetraodon PXR (tnPXR) or zebrafish PXR (zfPXR). B) The primary conjugated bile acid taurochenodeoxycholic acid (TCDCA) activates hPXR and tnPXR but not chPXR or zfPXR. C) The steroid 5β-pregnane-3,20-dione (5β-pregnanedione) activates all four PXRs shown. D) Nifedipine activates hPXR, chPXR, and zfPXR, but not tnPXR. The ordinate indicates fold induction compared to vehicle control in luciferase-based assay. Note that the scale of the ordinate is different in A) through D).

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BMC Biochemistry

ISSN: 1471-2091

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