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Figure 2 | BMC Biochemistry

Figure 2

From: The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species

Figure 2

FXR concentration-response curves. Ligand activation of FXRs from different species. A) The synthetic mammalian FXR activator GW4064 activates human FXR (hFXR) with high efficacy and submicromolar potency. GW4064 also activates Tetraodon FXR (tnFXR) and zebrafish FXR (zfFXR) but not Xenopus laevis FXR(xlFXR). B) T-0901317 activates hFXR, zfFXR, and tnFXR (although with lower efficacy compared to GW4064) but not xlFXR. C) The primary bile acid chenodeoxycholic acid (CDCA) activates hFXR and tnFXR but not zfFXR or xlFXR. D) The secondary bile acid lithocholic acid (LCA) activates hFXR, tnFXR, and zfFXR, but not xlFXR. The ordinate indicates fold induction compared to vehicle control in luciferase-based assay. Note that the scale of the ordinate is different in A) through D).

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