Table 1 Association and dissociation constants of RI and RII and Cα1 and Cα2
Analyt/Ligand (immobilized) | ka[M-1s-1] | kd[s] | KD[nM] |
|---|---|---|---|
hRIα/PKA-Cα1 myr | 1.6E + 6 | 200,0E-6 | 0,13 |
hRIα/PKA-Cα2 | 1.9E + 6 | 214,0E-6 | 0,11 |
hRIβ/PKA-Cα1 myr | 3.5E + 6 | 501,0E-6 | 0,15 |
hRIβ/PKA-Cα2 | 4.4E + 6 | 482,0E-6 | 0,11 |
hRIIα/PKA-Cα1 myr | 1.0E + 6 | 469,0E-6 | 0,48 |
hRIIα/PKA-Cα2 | 1.2E + 6 | 433,0E-6 | 0,35 |
hRIIβ/PKA-Cα1 myr | 0.5E + 6 | 797,0E-6 | 1,5 |
hRIIβ/PKA-Cα2 | 0.9E + 6 | 793,0E-6 | 0,9 |