Figure 4From: SUMO-1 regulates the conformational dynamics of Thymine-DNA Glycosylase regulatory domain and competes with its DNA binding activitySUMO-1 influences the TDG-DNA interaction. (A) 15N-1H HSQC spectra of TDG at 20 μM without dsDNA substrate (black) or in presence of 50 μM of a 37-mer dsDNA substrate containing a G:T mismatch (red). (B) 15N-1H HSQC spectra of TDG in presence of 120 μM SUMO-1 without DNA (black) or in presence of 50 μM of DNA substrate containing a G:T mismatch (red). Resonances of TDG-RD residues are annotated in bold and resonances of C-terminal residues in italic.Back to article page