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Figure 1 | BMC Biochemistry

Figure 1

From: SUMO-1 regulates the conformational dynamics of Thymine-DNA Glycosylase regulatory domain and competes with its DNA binding activity

Figure 1

Schematic representation of TDG domains and the SUMO-conjugation site (upper panel). Three-dimensional structure of the SUMO-1-modified TDG-CAT protein (ribbon and surface representations) determined by X-ray diffraction (14) with, indicated between brackets, the junctions of TDG N- and C-terminus. TDG-CAT is represented in grey and the interface with SUMO-1 in blue, SUMO-1 is colored in yellow. The SUMO-binding motifs (SBM1 and SBM2) are indicated in red and the catalytic residues in blue. Molecular models were generated using the Protein Data Bank (PDB) structure (PDB code 1WYW) and processed with the MolMol software (42).

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BMC Biochemistry

ISSN: 1471-2091

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