Figure 2

Primary sequence alignment of trypanosomal trans-sialidases. The amino acid sequence of T. congolense [EMBL: HE583287] TS1 e-1 was aligned with T. cruzi TS [EMBL: BAA09334.1, PDB: 3B69], T. brucei TS [EMBL: AAG32055.1] and T. rangeli SA [EMBL: AAC95493.1] based on a structural alignment of T. congolense TS1 e-1 with T. cruzi TS generated with Yasara during homology modeling. Amino acids, which have been proposed to be relevant for enzymatic activity are marked with black frames if conserved or with black frames and light grey background if not conserved. Positions with variations occurring in T. congolense TS1 or T. brucei TS [3] are highlighted by dark grey boxes.