All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases

Table 1 Complex formation with Dact1, Dact2, and Dact3

putative interactors (mouse unless other specified)
bold = positive for all paralogs		Dact1	Dact2	Dact3
Dact family (dimers)	Dact1	+	+	+
	Dact2	+	+	+
	Dact3	+	+	+
Dvl family	Dvl1	+	+	+
	Dvl2	+	+	+
	Dvl3	+	+	+
	dsh (fruit fly)	+	+	+
Vangl family	Vangl1	+	+	+
	Vangl2	+	-/+	+
	Vang/Stbm (fruit fly)	+	+	+
Casein Kinase 1δ/ε	CK1δ	+	+	+
	dbt/dco (fruit fly)	+	+	+
Protein Kinase A	PKA	+	+	+
Protein Kinase C	PKC	+	+	-/+
p120-catenin	p120-catenin	+	+	+
other catenins	α-catenin	-	-	-
	β-catenin	-	+	-/+
	δ-catenin	-/+	+	-
Casein Kinase 2s	CK2a1	-/+	-	-
	CK2a2	-	-	-
	CK2b	+	+	-
GSK3 family	GSK3α (human)	-/+	-/+	-
	GSK3β	-/+	-/+	-
HDAC1	HDAC1	+	+	-
LEF/TCF family	LEF1	-	+	-
	TCF1/TCF7	-	+	-
	TCF3	-	+	-
	TCF4	-	-/+	-
TGFβR family	Alk4	-	-	-
	Alk5	-/+	+	-

ISSN: 1471-2091