Figure 1

Ribbon diagrams showing differences in substrate-binding sites between Escherichia coli (bacterium) and Rigidoporus Lignosus (fungus) multicopper oxidases. Ribbon diagrams were created using PDB files deposited in the RCSB protein data bank via Swiss-PdbViewer 4.0.1. (a) E. coli CueO (PDB ID: 1KV7); (b) R. Lignosus laccase (PDB ID: 1V10); (c) The motif of E. coli CueO showing a α-helex (Leu351-Gly378) over the Cu I site; (d) The motif of R. Lignosus laccase showing the Cu I site exposed freely to solvent. Red ball presents copper ion in the active site of enzyme.