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Table 8 Insulin-stimulated amino acid clearance rates during the steady state phase of the hyperinsulinaemic euglycaemic euaminoacidaemic clamp in 8 normal and 7 diabetic pigs.

From: The existence of an insulin-stimulated glucose and non-essential but not essential amino acid substrate interaction in diabetic pigs

Plasma amino acid Normal pigs
(mL/kg·min)
Diabetic pigs
(mL/kg·min)
Essential:   
Arginine 5.2 ± 0.5 7.2 ± 1.4
Histidine 5.3 ± 0.7 5.7 ± 0.5
Isoleucine 7.0 ± 1.3 6.2 ± 0.7
Leucine 7.3 ± 1.0 7.3 ± 0.7
Lysine 7.4 ± 0.9 7.2 ± 1.1
Methionine 11.4 ± 1.4 16.1 ± 2.4
Phenylalanine 8.2 ± 1.3 9.3 ± 1.1
Threonine 5.2 ± 0.5 8.1 ± 1.3*
Tryptophan 2.7 ± 0.3 3.0 ± 0.6
Tyrosine 6.4 ± 0.7 14.3 ± 2.5
Valine 3.6 ± 0.8 2.8 ± 0.4
Non-essential:   
Alanine 3.2 ± 0.4 14.2 ± 2.4
Asparagine 9.5 ± 1.8 22.1 ± 5.4*
Aspartate 2.0 ± 0.2 0 ± 0
Cysteine 4.1 ± 0.8 6.7 ± 1.2
Glutamine 2.1 ± 0.2 2.4 ± 0.6
Glutamate 5.0 ± 0.6 10.6 ± 1.3
Glycine 2.9 ± 0.3 5.2 ± 1.5
Proline 4.9 ± 0.5 8.6 ± 0.9
Serine 6.5 ± 0.7 9.5 ± 1.9
  1. Normal pigs were infused with an amino acid mixture (Table 1) designed for normal pigs and diabetic pigs were infused with an amino acid mixture (Table 3) designed for diabetic pigs.
  2. Mean ± SEM, * P < .05, † P < .01 and ‡ P < .001 compared to normal pigs.