Table 7 Individual amino acid concentrations are shown at preclamp (basal) and at steady state during the hyperinsulinaemic euglycaemic euaminoacidaemic clamp in 7 diabetic pigs infused with an AA-mixture (Table 3) designed for diabetic pigs.
Plasma amino acid | Preclamp (basal) (μ mol/L) | Steady state clamp (μ mol/L) | Deviation From basal | |||
|---|---|---|---|---|---|---|
VC (%) | VC (%) | (%) | P -value | |||
Essential: | ||||||
Arginine | 99 ± 11 | 6 | 83 ± 9 | 8 | -16 | |
Histidine | 64 ± 6 | 3 | 69 ± 5 | 6 | 8 | |
Isoleucine | 194 ± 39 | 4 | 144 ± 25 | 6 | -26 | |
Leucine | 242 ± 41 | 5 | 214 ± 21 | 6 | -12 | |
Lysine | 114 ± 13 | 8 | 146 ± 13 | 6 | 28 | |
Methionine | 23 ± 2 | 8 | 27 ± 2 | 10 | 17 | |
Phenylalanine | 48 ± 4 | 6 | 50 ± 3 | 5 | 4 | |
Threonine | 105 ± 13 | 6 | 109 ± 12 | 7 | 4 | |
Tryptophan | 33 ± 2 | 7 | 32 ± 3 | 7 | -3 | |
Tyrosine | 39 ± 2 | 9 | 39 ± 3 | 8 | 0 | |
Valine | 507 ± 79 | 3 | 363 ± 51 | 5 | -28 | |
Non-essential: | ||||||
Alanine | 158 ± 32 | 6 | 180 ± 16 | 7 | 14 | |
Asparagine | 28 ± 4 | 15 | 34 ± 5 | 10 | 21 | |
Aspartate | 16 ± 3 | 6 | 19 ± 5 | 7 | 19 | |
Cysteine | 28 ± 3 | 4 | 34 ± 3 | 6 | 21 | 0.09 |
Glutamine | 375 ± 28 | 2 | 357 ± 33 | 5 | -5 | |
Glutamate | 90 ± 9 | 7 | 96 ± 8 | 11 | 7 | |
Glycine | 444 ± 72 | 3 | 546 ± 57 | 6 | 23 | |
Proline | 179 ± 13 | 6 | 211 ± 12 | 6 | 18 | 0.09 |
Serine | 93 ± 7 | 8 | 91 ± 7 | 8 | -2 | |