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Figure 4 | BMC Biochemistry

Figure 4

From: Strand-specific PCR of UV radiation-damaged genomic DNA revealed an essential role of DNA-PKcs in the transcription-coupled repair

Figure 4

The influence of gene transcriptional activity on the efficiency of the nucleotide excision repair of DNA damage in the c-myc gene induced by UV radiation. A: Alteration of c-myc expression in HL60 cells induced by DMSO, detected by immunoblotting analysis. HL60 cells were collected at 12, 24, 48, 72 and 96 h after the treatment with 0.5% or 1% (v/v) of DMSO. Non-DMSO-treated HL60 cells were used as control. B: The influence of gene transcriptional activity on the repair efficiency of DNA damage in the transcribed strand of the c-myc gene, detected by transcribed-strand specific PCR assay. HL60 cells were collected at 0, 4, 8, 24 and 36 h after the treatment with 1% (v/v) DMSO. Non-DMSO-treated HL60 cells were used as the control.

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