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Figure 9 | BMC Biochemistry

Figure 9

From: Soluble perlecan domain i enhances vascular endothelial growth factor-165 activity and receptor phosphorylation in human bone marrow endothelial cells

Figure 9

Model: PlnDI interactions with the VEGFR-2 signaling complex. N-terminal domain I of perlecan, unbound or bound to VEGF165, liberated by proteolytic cleavage (scissors) during extracellular matrix turnover stimulates angiogenesis by direct interactions with: 1) NRP-1; 2) VEGFR-2; and 3) NRP-1 and VEGFR-2. PlnDI may enhance VEGF165 stimulated pro-angiogenic events by stabilizing NRP-1/VEGF165/VEGFR-2 interactions.

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BMC Biochemistry

ISSN: 1471-2091

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