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Figure 6 | BMC Biochemistry

Figure 6

From: Identification of inhibitors of Plasmodium falciparum phosphoethanolamine methyltransferase using an enzyme-coupled transmethylation assay

Figure 6

Amodiaquine inhibits PfPMT function in yeast. Growth curves of wild-type (BY4741-pYes2.1) (A) and pem1Δpem2Δ- PfPMT (B) strains grown in minimal medium containing 4% galactose and 100 μM ethanolamine in the presence of 0 μM (1), 10 μM (2), 50 μM (3), or 100 μM (4) AQ. (C-E) Growth curves of wild-type (BY4741-pYes2.1) (C), pem1Δpem2Δ-pYes2.1 (D) and pem1Δpem2Δ-PfPMT (E) yeast strains grown in minimal medium containing 4% galactose and 2 mM ethanolamine in the presence of 0 μM AQ (5), 200 μM AQ (6), 200 μM AQ and 1 mM choline (7), or 1 mM choline (8).

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BMC Biochemistry

ISSN: 1471-2091

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