Table 2 Summary of expression of LGI1, LGI2, LGI3 and LGI4.
From: Similarity of molecular phenotype between known epilepsy gene LGI1 and disease candidate gene LGI2
Gene | BioGPS [23] Human GeneAtlas U133A.gcrma experiment | BioGPS [23] Mouse GeneAtlas GNF1 M.gcrma experiment | HPRD [24] (site of expression, selected only human brain regions) | Human Protein Atlas [25] (selected only strong and moderate expression in human brain tissues and cell lines) | SOURCE [26] (only top 5*) |
|---|---|---|---|---|---|
LGI1 | Most expressed in amygdala, prefrontal cortex, fetal brain, hypothalamus, caudate nucleus, cingulated cortex | Highly expressed in amygdala, hippocampus, dorsal striatum, cerebral cortex, frontal cortex and cortex, respectively | Brain, nervous system | - | Brain, ganglia, umbilical cord, embryonic tissue, nerve |
LGI2 | Expressed at levels around the median value in any tissue of the brain with a slight elevation in the olfactory bulb | Highly expressed in lower spinal cord with intermediate but elevated expression in upper spinal cord, trigeminal ganglion, substantia nigra and dorsal root ganglion | Amygdala, brain, caudate nucleus, cerebellum, corpus callosum, hippocampus, spinal cord, substantia nigra, subthalamic nucleus, thalamus | cerebellum(purkinje cells; strong, cells in granular layer; moderate, cells in molecular layer; moderate) Hippocampus (neuronal cells; moderate) Lateral ventricle (neuronal cells; moderate) D341 Med (Medulloblastoma cell line), SH-SY5Y (Metastatic neuroblastoma, clonal subline of neuroepithelioma cell line SK-N-SH) | Parathyroid, embryonic tissue, mixed, unclassified, spleen (brain is ranked at 15) |
LGI3 | Specifically expressed in prefrontal cortex | Highest levels in lower and upper spinal cord as well as substantia nigra | Brain | - | Nerve, skin, brain, prostate, pancreas |
LGI4 | Generally low but constant expression in tissues of the nervous system with slightly elevated levels in dorsal root ganglion | Most highly expressed in dorsal root ganglion, trigeminal ganglion and cerebellum respectively | Brain | - | Ganglia, pharynx, nerve, ear, eye |