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Figure 1 | BMC Biochemistry

Figure 1

From: Molecular characterization of tlyA gene product, Rv1694 of Mycobacterium tuberculosis: A non-conventional hemolysin and a ribosomal RNA methyl transferase

Figure 1

(A) Multiple sequence alignment of Rv1694 with pore forming hemolysins. Multiple sequence alignment (BCM search launcher) of Rv1694 (TlyA) of M. tb with TlyA sequences of S. hyodysenteria and H. pylori. TlyA of Mtb shows 58% homology with TlyA of both S. hyodysenteria (38% identity) and H. pylori (32% identity). TlyAs of all these bacteria also have K-D-K-E motif (indicated with inverted arrow) (â–¼) which were predicted to be signature motiffs of ribosomal RNA methyltransferases. (B) Alignment with ribosomal RNA methyltransferase: Homology of Rv1694 with ribosomal RNA methyltransferase (FtsJ/RrmJ) from E. coli (Multiple sequence alignment with ClustalW). TlyA of Mtb shows 48% homology with FtsJ/RrmJ.

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BMC Biochemistry

ISSN: 1471-2091

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