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Table 1 Major differences of four mKAT enzymes

From: Thermal stability, pH dependence and inhibition of four murine kynurenine aminotransferases

 

mKAT I

mKAT II

mKAT III

mKAT IV

Tm (°C)

69.8

65.9

64.8

66.5

t1/2 (min)

69.7

27.4

3.9

6.5

pKa

7.6

5.7

8.7

6.9

pH optima

9

7-8

9

8

Specific

co-substrate

α-ketobutyrate

α-ketoglutarate

α-ketobutyrate

α-ketoglutarate

Inhibitor

Indole-3-propionic acid

 

methionine

aspartate

  1. Tm: The midpoint temperature of the protein melting; t1/2: half life value at 65°C