Figure 4

The putative mechanisms of F1 peptide- and F2 peptide-mediated inhibition of the GST activity. A): Binding of the enzyme (blue) and substrate (red) results in formation of the enzyme-substrate complex, and then in liberation of the final product. B): Binding of the F1 peptide (black) and substrate (red) leads to formation of a new peptide-substrate complex inhibitor, which may non-competitively inhibit the enzyme activity. C): Binding of the F2 peptide (green) and substrate (red) leads to formation of a new peptide-substrate complex inhibitor, which may competitively inhibit the enzyme activity.