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Table 1 Peptide information and peptide-array blocking results

From: Prion protein self-peptides modulate prion interactions and conversion

peptide

amino acid sequence

position1

block2

equiv.3

NTG

KKRPKPGGGWNT

25-36

+/-

403

OR

GQPHGGGWGQ

61-95

++

396

TD2

GGGGWGQGGSHSQWNKPSK

89-107

++

198

AM

KTNMKHVAGAAAAGA

109-123

+/-

502

CO

LGSAMSRLPLIHFGNDYEDR

133-151

no

499*

CT

GENFTETDIKIMERVVEQMC

198-217

++

198

  1. 1 position of the amino acid sequence in mature ovine PrPC
  2. 2 effect of pre-incubation with peptide on binding of PrP to the peptide-array
  3. (-- no effect, +/- moderate blocking, ++ blocking)
  4. 3 minimal amount of molar excess of peptide needed to affect PrP binding
  5. (* highest amount of excess peptide tested)
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BMC Biochemistry

ISSN: 1471-2091

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