Figure 2

Effects of peptides on PrP to peptide-array binding pattern. No effect (A) on the peptide-array binding pattern and intensities was observed when PrP was pre-incubated with peptide CO (green line) compared to non-peptide pre-incubated PrP binding (grey bars). Only moderate inhibition of the binding pattern (B) was observed when PrP was pre-incubated with either peptide NTG (blue line) or peptide AM (orange line), whereas almost complete inhibition was observed when PrP was pre-incubated with either peptide OR (blue line), TD2 (green line) or CT (orange line). Minimal peptide concentration needed for blocking was determined (Table 1).