Skip to main content
Figure 5 | BMC Biochemistry

Figure 5

From: Biochemical characterization of bovine plasma thrombin-activatable fibrinolysis inhibitor (TAFI)

Figure 5

Bovine TAFIa attenuates clot lysis. The anti fibrinolytic function of bovine TAFIa was tested and compared to that of human TAFIa in a purified system. Clott formation was initiated by addition of thrombin to fibrinogen in the presence of CaCl2. Simultaneously, the dissolution of clot was generated by tPA and plasminogen addition. The change in turbidity was monitored at 405 nm (crosshairs). Upon addition of 1 μg of either bovine TAFI (filled circles) or human TAFI (filled squares), in the presence of Solulin, a delay in clot lysis was observed. A small anti fibrinolytic effect was observed upon addition of 1 μg of bovine TAFI (open circles) and human TAFI (open squares) in the absence of Solulin as well.

Back to article page