Figure 10
From: Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function
Comparison of zinc and copper binding sites in S100 proteins. (A) Human S100A12 dimer in the copper-bound state (PDB code 1ODB). Ribbons of the two subunits are in yellow and purple. Calcium ions are shown in grey and copper ion in cyan. Copper-binding residues are shown in ball and stick. (B) Superposition of the copper (and potentially zinc) binding site in S100A12 on zinc-binding sites of S100A7 (PDB code 2PSR) and S100B (PDB code 3CR2). Copper-binding residues of S100A12 and copper ion are in yellow, corresponding residues and zinc are in green for S100A7 and in cyan for S100B. The structures were superimposed using the program LSQKAB [59]. Part A of the figure was generated using MOLSCRIPT [60] and rendered with Raster3D [61], part B with CCP4mg [62]