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  1. Research article

    Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor

    Protein tyrosine phosphatases (PTPs) like dual specificity phosphatase 5 (DUSP5) and protein tyrosine phosphatase 1B (PTP1B) are drug targets for diseases that include cancer, diabetes, and vascular disorders ...

    Robert D. Bongard, Michael Lepley, Khushabu Thakur, Marat R. Talipov, Jaladhi Nayak, Rachel A. Jones Lipinski, Chris Bohl, Noreena Sweeney, Ramani Ramchandran, Rajendra Rathore and Daniel S. Sem

    BMC Biochemistry 2017 18:10

    Published on: 31 May 2017

  2. Research article

    Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase LdtMt2 by biapenem and tebipenem

    The carbapenem subclass of β-lactams is among the most potent antibiotics available today. Emerging evidence shows that, unlike other subclasses of β-lactams, carbapenems bind to and inhibit non-classical tran...

    Mario A. Bianchet, Ying H. Pan, Leighanne A. Brammer Basta, Harry Saavedra, Evan P. Lloyd, Pankaj Kumar, Rohini Mattoo, Craig A. Townsend and Gyanu Lamichhane

    BMC Biochemistry 2017 18:8

    Published on: 25 May 2017

  3. Research article

    Structural similarities and functional differences clarify evolutionary relationships between tRNA healing enzymes and the myelin enzyme CNPase

    Eukaryotic tRNA splicing is an essential process in the transformation of a primary tRNA transcript into a mature functional tRNA molecule. 5′-phosphate ligation involves two steps: a healing reaction catalyze...

    Gopinath Muruganandam, Arne Raasakka, Matti Myllykoski, Inari Kursula and Petri Kursula

    BMC Biochemistry 2017 18:7

    Published on: 16 May 2017

  4. Research article

    Binding of smoothelin-like 1 to tropomyosin and calmodulin is mutually exclusive and regulated by phosphorylation

    The smoothelin-like 1 protein (SMTNL1) can associate with tropomyosin (Tpm) and calmodulin (CaM), two proteins essential to the smooth muscle contractile process. SMTNL1 is phosphorylated at Ser301 by protein ...

    Annegret Ulke-Lemée, David Hao Sun, Hiroaki Ishida, Hans J. Vogel and Justin A. MacDonald

    BMC Biochemistry 2017 18:5

    Published on: 21 March 2017

  5. Research article

    Increased enzymatic hydrolysis of sugarcane bagasse by a novel glucose- and xylose-stimulated β-glucosidase from Anoxybacillus flavithermus subsp. yunnanensis E13T

    β-Glucosidase is claimed as a key enzyme in cellulose hydrolysis. The cellulosic fibers are usually entrapped with hemicelluloses containing xylose. So there is ongoing interest in searching for glucose- and x...

    Yang Liu, Rui Li, Jing Wang, Xiaohan Zhang, Rong Jia, Yi Gao and Hui Peng

    BMC Biochemistry 2017 18:4

    Published on: 16 March 2017

  6. Research article

    Interactions of histatin-3 and histatin-5 with actin

    Histatins are histidine rich polypeptides produced in the parotid and submandibular gland and secreted into the saliva. Histatin-3 and −5 are the most important polycationic histatins. They possess antimicrobi...

    Edna Blotnick, Asaf Sol, Gilad Bachrach and Andras Muhlrad

    BMC Biochemistry 2017 18:3

    Published on: 6 March 2017

  7. Research article

    Copper chelation and interleukin-6 proinflammatory cytokine effects on expression of different proteins involved in iron metabolism in HepG2 cell line

    In vertebrates, there is an intimate relationship between copper and iron homeostasis. Copper deficiency, which leads to a defect in ceruloplasmin enzymatic activity, has a strong effect on iron homeostasis re...

    Luca Marco Di Bella, Roberto Alampi, Flavia Biundo, Giovanni Toscano and Maria Rosa Felice

    BMC Biochemistry 2017 18:1

    Published on: 24 January 2017

  8. Research article

    Identification of replication-dependent and replication-independent linker histone complexes: Tpr specifically promotes replication-dependent linker histone stability

    There are 11 variants of linker histone H1 in mammalian cells. Beyond their shared abilities to stabilize and condense chromatin, the H1 variants have been found to have non-redundant functions, the mechanisms...

    Pei Zhang, Owen E. Branson, Michael A. Freitas and Mark R. Parthun

    BMC Biochemistry 2016 17:18

    Published on: 1 October 2016

  9. Research article

    Avoiding false discovery in biomarker research

    Human tyrosine-protein phosphatase non-receptor type substrate 1α (SIRPA) is a surface marker identified in cardiomyocytes differentiated from human embryonic stem cells. Our objective was to determine if circ...

    Pranali Patel, Uros Kuzmanov and Seema Mital

    BMC Biochemistry 2016 17:17

    Published on: 30 July 2016

  10. Research article

    Effect of mutations to amino acid A301 and F361 in thermostability and catalytic activity of the β-galactosidase from Bacillus subtilis VTCC-DVN-12-01

    Beta-galactosidase (EC 3.2.1.23), a commercially important enzyme, catalyses the hydrolysis of β-1,3- and β-1,4-galactosyl bonds of polymer or oligosaccharidesas well as transglycosylation of β-galactopyranosi...

    Thao Thi Nguyen, Hanh Van Vu, Nhung Thi Hong Nguyen, Tuyen Thi Do and Thanh Sy Le Nguyen

    BMC Biochemistry 2016 17:15

    Published on: 8 July 2016

  11. Research article

    Auto-thiophosphorylation activity of Src tyrosine kinase

    Intermolecular autophosphorylation at Tyr416 is a conserved mechanism of activation among the members of the Src family of nonreceptor tyrosine kinases. Like several other tyrosine kinases, Src can catalyze th...

    M. Zulema Cabail, Emily I. Chen, Antonius Koller and W. Todd Miller

    BMC Biochemistry 2016 17:13

    Published on: 7 July 2016

  12. Research article

    Molecular characterization of protein kinase C delta (PKCδ)-Smac interactions

    Protein kinase C δ (PKCδ) is known to be an important regulator of apoptosis, having mainly pro- but also anti-apoptotic effects depending on context. In a previous study, we found that PKCδ interacts with the...

    Christian Holmgren, Louise Cornmark, Gry Kalstad Lønne, Katarzyna Chmielarska Masoumi and Christer Larsson

    BMC Biochemistry 2016 17:11

    Published on: 23 May 2016

  13. Research article

    Tubulin is a molecular target of the Wnt-activating chemical probe

    In drug discovery research, cell-based phenotypic screening is an essential method for obtaining potential drug candidates. Revealing the mechanism of action is a key step on the path to drug discovery. Howeve...

    Yasunori Fukuda, Osamu Sano, Kenichi Kazetani, Koji Yamamoto, Hidehisa Iwata and Junji Matsui

    BMC Biochemistry 2016 17:9

    Published on: 20 May 2016

  14. Research article

    Conserved motif VIII of murine DNA methyltransferase Dnmt3a is essential for methylation activity

    Dnmt3a is a DNA methyltransferase that establishes de novo DNA methylation in mammals. The structure of the Dnmt3a C-terminal domain is similar to the bacterial M. HhaI enzyme, a well-studied prokaryotic DNA meth...

    Olga V. Lukashevich, Natalia A. Cherepanova, Renata Z. Jurkovska, Albert Jeltsch and Elizaveta S. Gromova

    BMC Biochemistry 2016 17:7

    Published on: 22 March 2016

  15. Research article

    1,2-Dichlorobenzene affects the formation of the phosphoenzyme stage during the catalytic cycle of the Ca2+-ATPase from sarcoplasmic reticulum

    1,2-Dichlorobenzene (1,2-DCB) is a benzene-derived molecule with two Cl atoms that is commonly utilized in the synthesis of pesticides. 1,2-DCB can be absorbed by living creatures and its effects on naturally-...

    Javier Vargas-Medrano, Jorge A. Sierra-Fonseca and Luis F. Plenge-Tellechea

    BMC Biochemistry 2016 17:5

    Published on: 11 March 2016

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